Pathology: commonly monitored glioblastoma markers: EFGR, EGFRvIII, PTEN, and MGMT

Joaquin Q Camara-Quintana; Ryan T Nitta; Gordon Li

doi:10.1016/j.nec.2012.01.011

Pathology: commonly monitored glioblastoma markers: EFGR, EGFRvIII, PTEN, and MGMT

Neurosurg Clin N Am. 2012 Apr;23(2):237-46, viii. doi: 10.1016/j.nec.2012.01.011. Epub 2012 Feb 22.

Authors

Joaquin Q Camara-Quintana¹, Ryan T Nitta, Gordon Li

Affiliation

¹ Department of Neurosurgery, Stanford University, 1201 Welch Road, MSLS p309, Stanford, CA 94305, USA.

PMID: 22440867
DOI: 10.1016/j.nec.2012.01.011

Abstract

The purpose of this article is to update the neurosurgical field on current molecular markers important to glioblastoma biology, treatment, and prognosis. The highlighted biologic markers in this article include epidermal growth factor receptor (EGFR), EGFR variant III (EGFRvIII), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and O6-methylguanine-DNA methyltransferase (MGMT).

Publication types

Review

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism*
Brain Neoplasms / genetics
Brain Neoplasms / metabolism
Brain Neoplasms / pathology*
DNA Methylation
DNA Modification Methylases / genetics
DNA Modification Methylases / metabolism
DNA Repair Enzymes / genetics
DNA Repair Enzymes / metabolism
ErbB Receptors / genetics
ErbB Receptors / metabolism
Glioblastoma / genetics
Glioblastoma / metabolism
Glioblastoma / pathology*
Humans
PTEN Phosphohydrolase / genetics
PTEN Phosphohydrolase / metabolism
Promoter Regions, Genetic
Tumor Suppressor Proteins / genetics
Tumor Suppressor Proteins / metabolism

Substances

Biomarkers, Tumor
Tumor Suppressor Proteins
epidermal growth factor receptor VIII
DNA Modification Methylases
MGMT protein, human
EGFR protein, human
ErbB Receptors
PTEN Phosphohydrolase
PTEN protein, human
DNA Repair Enzymes