ALK and MYCN: when two oncogenes are better than one

Zhihui Liu; Carol J Thiele

doi:10.1016/j.ccr.2012.03.004

ALK and MYCN: when two oncogenes are better than one

Cancer Cell. 2012 Mar 20;21(3):325-6. doi: 10.1016/j.ccr.2012.03.004.

Authors

Zhihui Liu¹, Carol J Thiele

Affiliation

¹ Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Abstract

Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer Cell, Zhu et al. describe a mechanism by which ALK and MYCN synergistically induce neuroblastoma in the zebrafish model system.

Publication types

Comment

Grants and funding

ZIA BC010788-04/Intramural NIH HHS/United States