Abstract
The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.
This journal is © The Royal Society of Chemistry 2012
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Calcitonin / chemistry*
-
Disulfides / chemical synthesis
-
Disulfides / chemistry*
-
Maleimides / chemical synthesis
-
Maleimides / chemistry*
-
Models, Molecular
-
Phenol / chemical synthesis
-
Phenol / chemistry*
-
Polymerization
-
Polymers / chemical synthesis
-
Polymers / chemistry*
-
Salmon
-
Sulfhydryl Compounds / chemical synthesis
-
Sulfhydryl Compounds / chemistry
Substances
-
Disulfides
-
Maleimides
-
Polymers
-
Sulfhydryl Compounds
-
maleimide
-
Phenol
-
Calcitonin