Preparation of functional phosphorus zwitterions from activated alkanes, aldehydes, and tributylphosphine: synthesis of polysubstituted furo[3,2-c]coumarins

Chia-Jui Lee; Yeong-Jiunn Jang; Zong-Ze Wu; Wenwei Lin

doi:10.1021/ol3005479

Preparation of functional phosphorus zwitterions from activated alkanes, aldehydes, and tributylphosphine: synthesis of polysubstituted furo[3,2-c]coumarins

Org Lett. 2012 Apr 6;14(7):1906-9. doi: 10.1021/ol3005479. Epub 2012 Mar 21.

Authors

Chia-Jui Lee¹, Yeong-Jiunn Jang, Zong-Ze Wu, Wenwei Lin

Affiliation

¹ Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

PMID: 22436030
DOI: 10.1021/ol3005479

Abstract

A general preparation of new types of highly functional phosphorus zwitterions is realized via tandem three-component reactions using the corresponding functional alkanes, aldehydes, and Bu(3)P. Starting from our novel zwitterions as synthetic reagents with commercially available acid chlorides in a one-step procedure provides an attractive approach toward furo[3,2-c]coumarins.