Synthesis and evaluation of anticancer natural product analogues based on angelmarin: targeting the tolerance towards nutrient deprivation

Jakob Magolan; Nathan B P Adams; Hiroko Onozuka; Natasha L Hungerford; Hiroyasu Esumi; Mark J Coster

doi:10.1002/cmdc.201100564

Synthesis and evaluation of anticancer natural product analogues based on angelmarin: targeting the tolerance towards nutrient deprivation

ChemMedChem. 2012 May;7(5):766-70. doi: 10.1002/cmdc.201100564. Epub 2012 Mar 16.

Authors

Jakob Magolan¹, Nathan B P Adams, Hiroko Onozuka, Natasha L Hungerford, Hiroyasu Esumi, Mark J Coster

Affiliation

¹ Eskitis Institute for Cell and Molecular Therapies (N75), Griffith University, Nathan, QLD, Australia.

PMID: 22431333
DOI: 10.1002/cmdc.201100564

Abstract

Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient-deprived, resistant cancer cells. Through structure-activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use
Biological Products / chemistry
Cell Line, Tumor
Cell Survival / drug effects
Coumarins / chemical synthesis*
Coumarins / chemistry
Coumarins / pharmacology
Drug Screening Assays, Antitumor
Food
Humans
Inhibitory Concentration 50
Molecular Structure
Pancreatic Neoplasms / drug therapy
Plant Extracts / chemical synthesis*
Plant Extracts / chemistry
Plant Extracts / pharmacology
Stereoisomerism
Stress, Physiological / physiology
Structure-Activity Relationship

Substances

Antineoplastic Agents
Biological Products
Coumarins
Plant Extracts
angelmarin