[VIM-2 metallo-ß-lactamase gen detection in a class 1 integron associated to bla(CTX-M-2) in a Pseudomonas aeruginosa clinical isolate in Uruguay: first communication]

Rev Argent Microbiol. 2011 Jul-Sep;43(3):198-202. doi: 10.1590/S0325-75412011000300004.
[Article in Spanish]

Abstract

In order to analyze the presence of metallo-ß-lactamase in our country, we included in this study Pseudomonas aeruginosa isolates causing nosocomial infections in a hospital from Uruguay. The presence of a metallo-ß-lactamase VIM-2 in a class 1 integron and of an extended spectrum -lactamase CTX-M-2 was detected in one isolate. This is the first report of both genes, bla(CTX-M-2) and bla(VIM-2),in the same P. aeruginosa isolate. Although carbapenemases have been extensively documented in the world, this is the first report of an acquired metallo-ß-lactamase with carbapenemase activity in pathogenic bacteria in Uruguay.

MeSH terms

  • Bacterial Proteins / genetics*
  • Carbapenems / pharmacology
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Genes, Bacterial*
  • Humans
  • Integrons / genetics*
  • Pseudomonas Infections / epidemiology
  • Pseudomonas Infections / microbiology*
  • Pseudomonas aeruginosa / enzymology
  • Pseudomonas aeruginosa / genetics*
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / microbiology
  • Uruguay / epidemiology
  • beta-Lactam Resistance / genetics*
  • beta-Lactamases / genetics*

Substances

  • Bacterial Proteins
  • Carbapenems
  • beta-lactamase CTX-2
  • beta-lactamase bla(vim-2)
  • beta-Lactamases