Abstract
A transdermal formulation of indomethacin (IMC) was developed by incorporation into cholesteryl cetyl carbonate (CCC). The liquid crystalline phase properties of the IMC-CCC mixture were detected by polarized light microscopy and differential scanning calorimetry. A low drug loading was obtained (1-5 %) similar to that used in conventional topical IMC in a clinical setting. A controlled release of IMC was found over 12 h. A low amount of IMC in 1 % IMC-CCC permeated the stratum corneum. Further formulation development has been carried out by the addition of lauryl alcohol into 5 % IMC-CCC mixture it was found that the permeation of IMC was significantly improved to 45 % within 24 h.
MeSH terms
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Administration, Cutaneous
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Animals
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Animals, Newborn
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / metabolism
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Calorimetry, Differential Scanning
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Chemistry, Pharmaceutical
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Cholesterol Esters / chemistry*
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Delayed-Action Preparations
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Dodecanol / chemistry
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Drug Carriers*
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Drug Stability
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Hydrogen-Ion Concentration
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Indomethacin / administration & dosage*
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Indomethacin / chemistry
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Indomethacin / metabolism
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Kinetics
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Liquid Crystals
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Microscopy, Polarization
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Permeability
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Skin / metabolism
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Skin Absorption
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Skin Temperature
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Solubility
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Swine
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Technology, Pharmaceutical / methods
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Transition Temperature
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cholesterol Esters
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Delayed-Action Preparations
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Drug Carriers
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cholesteryl cetyl carbonate
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Dodecanol
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Indomethacin