Triterpene saponins from the roots of Dipsacus asper and their protective effects against the Aβ(25-35) induced cytotoxicity in PC12 cells

Fitoterapia. 2012 Jul;83(5):843-8. doi: 10.1016/j.fitote.2012.03.004. Epub 2012 Mar 13.

Abstract

Three new triterpene saponins, named asperosaponin A-C (1-3), together with seven known triterpene saponins (4-10) were isolated from the roots of Dipsacus asper. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1-3, 6-10 had significantly protective effects in PC12 cells against the Aβ(25-35) induced cytotoxicity. All the compounds isolated showed no cytotoxic activity against three human cancer cell lines, A-549, Bel-7402 and BGC-823.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Gland Neoplasms / chemically induced
  • Adrenal Gland Neoplasms / drug therapy*
  • Amyloid beta-Peptides
  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Dipsacaceae / chemistry*
  • Humans
  • Molecular Structure
  • PC12 Cells
  • Peptide Fragments
  • Pheochromocytoma / chemically induced
  • Pheochromocytoma / drug therapy*
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Roots / chemistry
  • Rats
  • Saponins / isolation & purification
  • Saponins / pharmacology
  • Saponins / therapeutic use*

Substances

  • 3-O-(3',4'-O-acetyl)-arabinopyranosyl hederagenin 28-O-glucopyranosyl-(1-6)-glucopyranoside
  • 3-O-arabinopyranosyl hederagenin 28-O-glucopyranosyl-(1-6)-glucopyranoside (3-C-28)
  • 3-O-arabinopyranosyl oleanolic acid
  • Amyloid beta-Peptides
  • Antineoplastic Agents, Phytogenic
  • Peptide Fragments
  • Plant Extracts
  • Saponins