Abstract
Recent efforts to understand the molecular networks governing normal T cell development and driving the neoplastic transformation of T cells have brought to light the involvement of microRNAs (miRNAs), a class of noncoding RNAs of approximately 22 nucleotides that regulate gene expression at the posttranscriptional level. In the present review, we compare the expression profiles of miRNAs in normal T cell development to that of transformed T cells using as a model adult T cell leukemia/lymphoma, an aggressive malignancy of mature CD4+ T cells that is caused by infection with human T cell leukemia virus type 1.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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CD4-Positive T-Lymphocytes / metabolism
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CD4-Positive T-Lymphocytes / pathology*
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CD4-Positive T-Lymphocytes / virology
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Cell Line
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Viral
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Gene Expression Regulation, Neoplastic
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HTLV-I Infections / genetics
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HTLV-I Infections / pathology
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Human T-lymphotropic virus 1 / genetics*
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Human T-lymphotropic virus 1 / metabolism
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Human T-lymphotropic virus 1 / pathogenicity*
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Humans
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Leukemia-Lymphoma, Adult T-Cell / genetics
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Leukemia-Lymphoma, Adult T-Cell / pathology
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Leukemia-Lymphoma, Adult T-Cell / virology
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MicroRNAs / genetics*
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MicroRNAs / metabolism*
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RNA, Messenger / metabolism
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Transcriptome