The microRNA regulatory network in normal- and HTLV-1-transformed T cells

Adv Cancer Res. 2012:113:45-83. doi: 10.1016/B978-0-12-394280-7.00002-6.

Abstract

Recent efforts to understand the molecular networks governing normal T cell development and driving the neoplastic transformation of T cells have brought to light the involvement of microRNAs (miRNAs), a class of noncoding RNAs of approximately 22 nucleotides that regulate gene expression at the posttranscriptional level. In the present review, we compare the expression profiles of miRNAs in normal T cell development to that of transformed T cells using as a model adult T cell leukemia/lymphoma, an aggressive malignancy of mature CD4+ T cells that is caused by infection with human T cell leukemia virus type 1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / pathology*
  • CD4-Positive T-Lymphocytes / virology
  • Cell Line
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Viral
  • Gene Expression Regulation, Neoplastic
  • HTLV-I Infections / genetics
  • HTLV-I Infections / pathology
  • Human T-lymphotropic virus 1 / genetics*
  • Human T-lymphotropic virus 1 / metabolism
  • Human T-lymphotropic virus 1 / pathogenicity*
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / genetics
  • Leukemia-Lymphoma, Adult T-Cell / pathology
  • Leukemia-Lymphoma, Adult T-Cell / virology
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • RNA, Messenger / metabolism
  • Transcriptome

Substances

  • MicroRNAs
  • RNA, Messenger