Bioactive diterpenes from Callicarpa longissima

Yuan-Wei Liu; Yuan-Bin Cheng; Chia-Ching Liaw; Chung-Hsiung Chen; Jih-Hwa Guh; Tsong-Long Hwang; Ji-Shu Tsai; Won-Bo Wang; Ya-Ching Shen

doi:10.1021/np200932k

Bioactive diterpenes from Callicarpa longissima

J Nat Prod. 2012 Apr 27;75(4):689-93. doi: 10.1021/np200932k. Epub 2012 Mar 19.

Authors

Yuan-Wei Liu¹, Yuan-Bin Cheng, Chia-Ching Liaw, Chung-Hsiung Chen, Jih-Hwa Guh, Tsong-Long Hwang, Ji-Shu Tsai, Won-Bo Wang, Ya-Ching Shen

Affiliation

¹ School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan.

PMID: 22429052
DOI: 10.1021/np200932k

Abstract

Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1-4), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17),13-dien-15-oic acid, 5-hydroxy-3,6,7,4'-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification*
Anti-Inflammatory Agents / pharmacology*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Callicarpa / chemistry*
Crystallography, X-Ray
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology*
Drug Screening Assays, Antitumor
Humans
Male
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Leaves / chemistry

Substances

Anti-Inflammatory Agents
Antineoplastic Agents, Phytogenic
Diterpenes