Abstract
Nanoscale coordination polymers containing exceptionally high loadings of bisphosphonates were coated with single lipid bilayers to control the drug release kinetics and functionalized with a targeting ligand to endow cell-targeting capability, leading to much enhanced cytotoxicity against human lung and pancreatic cancer cells.
This journal is © The Royal Society of Chemistry 2012
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacokinetics
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Antineoplastic Agents / pharmacology
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Calcium / chemistry
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Cell Line, Tumor
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Cell Survival / drug effects
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Diphosphonates / chemistry*
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Diphosphonates / pharmacology
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Humans
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Imidazoles / chemistry
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Imidazoles / pharmacology
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Lipid Bilayers / metabolism
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Nanoparticles / chemistry*
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Nanoparticles / ultrastructure
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Pamidronate
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Polymers / chemistry*
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Zoledronic Acid
Substances
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Antineoplastic Agents
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Diphosphonates
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Imidazoles
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Lipid Bilayers
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Polymers
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Zoledronic Acid
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Pamidronate
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Calcium