Abstract
Breaking the mold: Inhibition of toxic amyloid-β (Aβ) aggregates and disruption of Cu-Aβ with subsequent redox-silencing of Cu have been considered promising strategies against Alzheimer's disease. The design and proof of concept of simple peptides containing a Cu-chelating/redox-silencing unit and an Aβ-aggregation inhibition unit (β-sheet breaker) is described (see scheme).
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Amyloid / antagonists & inhibitors*
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Amyloid / chemistry*
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Amyloid / metabolism
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Amyloid beta-Peptides / antagonists & inhibitors*
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Amyloid beta-Peptides / chemistry*
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Amyloid beta-Peptides / metabolism
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Chelating Agents / chemistry*
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Chelating Agents / pharmacology
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Copper / chemistry*
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Copper / pharmacology
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Models, Molecular
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Molecular Sequence Data
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Oxidation-Reduction
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Peptide Fragments / metabolism
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Protein Binding
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Protein Structure, Secondary
Substances
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Amyloid
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Amyloid beta-Peptides
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Chelating Agents
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Peptide Fragments
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Copper