Lysosomal disorders associated with leukoencephalopathy

Semin Neurol. 2012 Feb;32(1):51-4. doi: 10.1055/s-0032-1306386. Epub 2012 Mar 15.

Abstract

Metachromatic leukodystrophy and Krabbe's disease are among the most widely recognized causes of leukodystrophy. However, white matter changes have been described in several other lysosomal storage disorders. These conditions are summarized and those associated with hypomyelination are reviewed in more detail.

Publication types

  • Review

MeSH terms

  • Brain / pathology
  • Brain Diseases / complications
  • Brain Diseases / diagnosis
  • Demyelinating Diseases / complications
  • Demyelinating Diseases / pathology
  • Fucosidosis / complications
  • Fucosidosis / diagnosis
  • Fucosidosis / pathology
  • Gangliosidosis, GM1 / complications
  • Gangliosidosis, GM1 / diagnosis
  • Gangliosidosis, GM1 / pathology
  • Humans
  • Leukodystrophy, Globoid Cell / complications*
  • Leukodystrophy, Globoid Cell / pathology
  • Leukodystrophy, Globoid Cell / therapy
  • Leukodystrophy, Metachromatic / complications*
  • Leukodystrophy, Metachromatic / diagnosis
  • Leukodystrophy, Metachromatic / pathology
  • Leukodystrophy, Metachromatic / therapy
  • Leukoencephalopathies / diagnosis
  • Leukoencephalopathies / etiology*
  • Leukoencephalopathies / metabolism
  • Lysosomal Storage Diseases / complications*
  • Lysosomal Storage Diseases / diagnosis
  • Lysosomal Storage Diseases / pathology
  • Lysosomal Storage Diseases / therapy
  • Sialic Acid Storage Disease / complications
  • Sialic Acid Storage Disease / diagnosis
  • Sialic Acid Storage Disease / pathology