Haworforbins A-C, new phenolics from Haworthia cymbiformis

Fumie Yamasaki; Shoko Machida; Asami Nakata; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Osamu Shirota; Naoyuki Hagane; Tadayoshi Sugizaki; Hiroshi Morita

doi:10.1007/s11418-012-0647-x

Haworforbins A-C, new phenolics from Haworthia cymbiformis

J Nat Med. 2013 Jan;67(1):212-6. doi: 10.1007/s11418-012-0647-x. Epub 2012 Mar 16.

Authors

Fumie Yamasaki¹, Shoko Machida, Asami Nakata, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Osamu Shirota, Naoyuki Hagane, Tadayoshi Sugizaki, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.

PMID: 22421814
DOI: 10.1007/s11418-012-0647-x

Abstract

Two new isocoumarin glucosides, haworforbins A (1) and B (2), and a new chromone, haworforbin C (3), have been isolated from Haworthia cymbiformis. Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Haworforbin C (3) exhibited moderate inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Glucosides / chemistry*
Glucosides / pharmacology*
Lipopolysaccharides / pharmacology
Magnetic Resonance Spectroscopy
Magnoliopsida / chemistry*
Mice
Nitric Oxide / metabolism
Nitric Oxide Synthase Type II / metabolism
Phenols / chemistry*
Phenols / pharmacology*

Substances

Glucosides
Lipopolysaccharides
Phenols
Nitric Oxide
Nitric Oxide Synthase Type II