The aim of the present study was to investigate the psychometric properties of the Padua Inventory in Chinese college samples. Three different samples (N1 = 1,939, N2 = 1,341, and N3 = 298) of Chinese college students were recruited. Exploratory factor analyses yielded a four-factor structure which was similar to that found in previous studies. Further, present results showed good internal consistency as well as convergent and divergent validity with the subscales of the Symptom Checklist-90 and the Penn State Worry Questionnaire. Although no sex difference was found on total score, women had significantly higher scores on Factor 2 (Urges and worries of losing control over motor behaviors) and Factor 4 (Checking), while men had significantly higher scores on Factor 3 (Contamination). Implications of ter the results and directions for research are discussed.