TachoSil for postinfarction ventricular free wall rupture

Interact Cardiovasc Thorac Surg. 2012 Jun;14(6):866-7. doi: 10.1093/icvts/ivs085. Epub 2012 Mar 14.

Abstract

Despite a decline in the last three decades, postinfarction ventricular free wall rupture still complicates more than 3% of acute ST-elevation myocardial infarctions and remains a surgical challenge. TachoSil (Nycomed, Zurich, Switzerland) is an equine collagen patch coated with human fibrinogen and human thrombin, which has recently been used for haemostasis in cardiovascular surgery, but its potential usefulness in free wall rupture has not been reported. Initial clinical experience with an on-pump sutureless technique without cardioplegia, using wide TachoSil patching to achieve free wall rupture repair, has been described.

MeSH terms

  • Aged
  • Cardiac Surgical Procedures*
  • Cardiac Tamponade / etiology
  • Cardiac Tamponade / surgery
  • Cardiopulmonary Bypass
  • Drug Combinations
  • Female
  • Fibrinogen / therapeutic use*
  • Heart Rupture, Post-Infarction / etiology
  • Heart Rupture, Post-Infarction / surgery*
  • Hemostatic Techniques*
  • Hemostatics / therapeutic use*
  • Humans
  • Male
  • Thrombin / therapeutic use*
  • Treatment Outcome

Substances

  • Drug Combinations
  • Hemostatics
  • TachoSil
  • Fibrinogen
  • Thrombin