Terpenoids from the octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

Cheng-Hung Lee; Chia-Ying Kao; Shih-Yao Kao; Chih-Han Chang; Jui-Hsin Su; Tsong-Long Hwang; Yueh-Hsiung Kuo; Zhi-Hong Wen; Ping-Jyun Sung

doi:10.3390/md10020427

Terpenoids from the octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

Mar Drugs. 2012 Feb;10(2):427-438. doi: 10.3390/md10020427. Epub 2012 Feb 15.

Authors

Cheng-Hung Lee^{1

2

3}, Chia-Ying Kao^{4

5}, Shih-Yao Kao^{4

5}, Chih-Han Chang¹, Jui-Hsin Su^{4

5

6}, Tsong-Long Hwang⁷, Yueh-Hsiung Kuo⁸, Zhi-Hong Wen⁶, Ping-Jyun Sung^{4

5

6}

Affiliations

¹ Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
² Department of Nutrition, HungKuang University, Taichung 433, Taiwan.
³ Department of Orthopedics, Taichung Veterans General Hospital, Taichung 407, Taiwan.
⁴ Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
⁵ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
⁶ Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
⁷ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
⁸ School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources and Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan.

Abstract

A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.

Keywords: Lobophytum; Menella; cembrane; elastase; germacrane; lobocrassin; menelloide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / metabolism*
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
Anti-Inflammatory Agents, Non-Steroidal / metabolism
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Aquaculture
Complex Mixtures / chemistry
Complex Mixtures / pharmacology
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / metabolism
Diterpenes / pharmacology
Drug Discovery
Endangered Species
Humans
Leukocyte Elastase / metabolism
Molecular Structure
Neutrophil Activation / drug effects
Neutrophils / drug effects
Neutrophils / immunology
Neutrophils / metabolism
Pacific Ocean
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification
Sesquiterpenes / metabolism
Sesquiterpenes / pharmacology
Stereoisomerism
Taiwan
Terpenes / chemistry
Terpenes / isolation & purification*
Terpenes / metabolism
Terpenes / pharmacology*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Complex Mixtures
Diterpenes
Sesquiterpenes
Terpenes
lobocrassin F
menelloide E
Leukocyte Elastase