Abstract
Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p < 0.05), compared with model control group. However, the arterial blood pressure of normal rats showed no significant changes during long-term oral treatment with high dose JCP (p > 0.05). Furthermore, effect of JCP on angiotensin II (Ang II) concentration of plasma had no significance (p > 0.05), but JCP significantly inhibited the Ang II concentration in RVHs' kidney (p < 0.05). The kidney should be the target site of JCP.
Keywords:
angiotensin II; blood pressure; collagen peptide; jellyfish; kidney.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Angiotensin II / blood
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Angiotensin II / metabolism
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Angiotensin-Converting Enzyme Inhibitors / administration & dosage
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Angiotensin-Converting Enzyme Inhibitors / metabolism
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Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
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Animals
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Antihypertensive Agents / administration & dosage
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Antihypertensive Agents / metabolism
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Antihypertensive Agents / therapeutic use*
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Blood Pressure / drug effects
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Collagen / administration & dosage
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Collagen / metabolism
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Collagen / therapeutic use*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Heart Rate / drug effects
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Hypertension, Renovascular / blood
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Hypertension, Renovascular / drug therapy*
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Hypertension, Renovascular / metabolism
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Kidney / drug effects
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Kidney / metabolism
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Male
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Peptide Fragments / administration & dosage
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Peptide Fragments / metabolism
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Peptide Fragments / therapeutic use*
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Rats
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Rats, Wistar
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Scyphozoa / metabolism*
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Time Factors
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Antihypertensive Agents
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Peptide Fragments
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Angiotensin II
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Collagen