Abstract
The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described.
Keywords:
chemical modification; synthesis; terpene hydroquinone; terpene quinone.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Infective Agents / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Antineoplastic Agents / chemical synthesis
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Chemistry, Pharmaceutical
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Humans
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Hydroquinones / chemical synthesis*
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Quinones / chemical synthesis*
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Terpenes / chemical synthesis*
Substances
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Anti-Infective Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Hydroquinones
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Quinones
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Terpenes