Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis

Mar Drugs. 2012 Feb;10(2):319-328. doi: 10.3390/md10020319. Epub 2012 Feb 3.

Abstract

Four novel amicoumacins, namely lipoamicoumacins A-D (1-4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.

Keywords: Bacillus subtilis; antibacterial; cytotoxicity; lipoamicoumacin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Aquatic Organisms / isolation & purification
  • Aquatic Organisms / metabolism*
  • Bacillus subtilis / isolation & purification
  • Bacillus subtilis / metabolism*
  • Coumarins / adverse effects
  • Coumarins / chemistry
  • Coumarins / isolation & purification
  • Coumarins / pharmacology*
  • Drug Discovery
  • Fermentation
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • HeLa Cells
  • Humans
  • Indian Ocean
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Proteobacteria / drug effects
  • Structure-Activity Relationship
  • Thioctic Acid / analogs & derivatives
  • Thioctic Acid / chemistry

Substances

  • Anti-Bacterial Agents
  • Coumarins
  • bacisarcin C
  • amicoumacin A
  • Thioctic Acid
  • lipoamide