New cytotoxic cembranolides from the soft coral Lobophytum michaelae

Shang-Kwei Wang; Chang-Yih Duh

doi:10.3390/md10020306

New cytotoxic cembranolides from the soft coral Lobophytum michaelae

Mar Drugs. 2012 Feb;10(2):306-318. doi: 10.3390/md10020306. Epub 2012 Jan 31.

Authors

Shang-Kwei Wang¹, Chang-Yih Duh^{2

3}

Affiliations

¹ Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
² Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
³ Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

Abstract

Six new cembranolides, michaolides L-Q (1-6), and a known cembranolide, lobomichaolide (7) were isolated from the CH₂Cl₂ extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated.

Keywords: Lobophytum michaelae; cembranolides; cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Antiviral Agents / chemistry
Antiviral Agents / isolation & purification
Antiviral Agents / pharmacology*
Cell Line, Tumor
Cytomegalovirus / drug effects
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Drug Discovery
Humans
Inhibitory Concentration 50
Lactones / chemistry
Lactones / isolation & purification
Lactones / pharmacology
Marine Toxins / chemistry
Marine Toxins / isolation & purification
Marine Toxins / pharmacology*
Mice
Molecular Structure
Neoplasms / drug therapy
Pacific Ocean
Stereoisomerism
Taiwan

Substances

Antineoplastic Agents
Antiviral Agents
Diterpenes
Lactones
Marine Toxins
lobomichaolide