Abstract
Dihomo-γ-linolenic acid (DGLA) is one of the polyunsaturated fatty acids, and is expected to show anti-allergic activity. We examined the effects of supplementation with DGLA-enriched oil (450 mg as free DGLA) for 4 weeks in healthy adults in a randomized controlled study. The DGLA composition in the total fatty acids of serum phospholipids increased from 2.0 to 3.4%, and returned to the initial level after a 4-week washout. No side effects or changes in blood biochemical parameters were observed. These results indicate that serum DGLA content can be safely increased by supplementation with 450 mg DGLA under these conditions.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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8,11,14-Eicosatrienoic Acid / administration & dosage*
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8,11,14-Eicosatrienoic Acid / chemistry
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8,11,14-Eicosatrienoic Acid / pharmacokinetics
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Administration, Oral
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Adult
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Anti-Allergic Agents / administration & dosage*
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Anti-Allergic Agents / chemistry
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Anti-Allergic Agents / pharmacokinetics
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Arachidonic Acids / blood
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Dietary Supplements
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Docosahexaenoic Acids / blood
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Eicosapentaenoic Acid / blood
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Female
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Humans
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Male
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Phospholipids / blood
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Young Adult
Substances
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Anti-Allergic Agents
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Arachidonic Acids
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Phospholipids
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Docosahexaenoic Acids
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Eicosapentaenoic Acid
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8,11,14-Eicosatrienoic Acid