Abstract
Chondroitin sulfate (CS) is a sulfated polysaccharide involved in a myriad of biological processes. Due to the variable sulfation pattern of CS polymer chains, the need to study in detail structure-activity relationships regarding CS biomedical features has provoked much interest in obtaining synthetic CS species. This paper reviews two decades of synthetic and semi-synthetic CS oligosaccharides, polysaccharides, and glycomimetics obtained by chemical, chemoenzymatic, enzymatic, and microbiological-chemical strategies.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biocatalysis
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Biomimetic Materials / chemical synthesis*
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Biotinylation
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Carbohydrate Sequence
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Chondroitin Sulfates / biosynthesis
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Chondroitin Sulfates / chemical synthesis*
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Combinatorial Chemistry Techniques
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Galactosamine / chemistry
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Glucose / chemistry
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Glucuronic Acid / chemistry
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Molecular Sequence Data
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Oligosaccharides / biosynthesis
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Oligosaccharides / chemical synthesis*
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Small Molecule Libraries
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Structure-Activity Relationship
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Sulfates / chemistry*
Substances
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Oligosaccharides
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Small Molecule Libraries
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Sulfates
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Galactosamine
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Glucuronic Acid
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Chondroitin Sulfates
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Glucose