Contactless NMR spectroscopy on a chip

Anal Chem. 2012 Apr 17;84(8):3696-702. doi: 10.1021/ac300204z. Epub 2012 Apr 3.

Abstract

Inductively coupled planar resonators offer convenient integration of high-resolution NMR spectroscopy with microfluidic lab-on-a-chip devices. Planar spiral resonators are fabricated lithographically either by gold electroplating or by etching Cu laminated with polyimide. Their performance is characterized by NMR imaging as well as spectroscopy. A single-scan limit of detection LOD(t) = 0.95 nmol s(1/2) was obtained from sample volumes around 1 μL. The sensitivity of this approach is similar to that obtained by microstripline and microslot probes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Limit of Detection
  • Magnetic Resonance Spectroscopy*
  • Microfluidic Analytical Techniques* / instrumentation
  • Microfluidic Analytical Techniques* / methods