Suspected opioid overdose case resolved by CYP2D6 genotyping

Ther Drug Monit. 2012 Apr;34(2):121-3. doi: 10.1097/FTD.0b013e31824a1e21.

Abstract

A 14-year-old female with suspected narcotic overdose had CYP2D6 genotyping performed to verify opiate intoxication. The role of pharmacogenetics in pain management and individualization of opiate pharmacotherapy is discussed.

Publication types

  • Case Reports

MeSH terms

  • Acetaminophen / administration & dosage
  • Adolescent
  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / adverse effects*
  • Analgesics, Opioid / metabolism
  • Caffeine / administration & dosage
  • Codeine / administration & dosage
  • Codeine / adverse effects*
  • Codeine / metabolism
  • Cytochrome P-450 CYP2D6 / genetics*
  • Drug Combinations
  • Drug Overdose
  • Female
  • Genotype
  • Humans
  • Pain / drug therapy
  • Pharmacogenetics

Substances

  • Analgesics, Opioid
  • Drug Combinations
  • Acetaminophen
  • Caffeine
  • Cytochrome P-450 CYP2D6
  • Codeine