Biochemistry to the rescue: a ClC-2 auxiliary subunit provides a tangible link to leukodystrophy

Merritt C Maduke; Richard J Reimer

doi:10.1016/j.neuron.2012.02.012

Biochemistry to the rescue: a ClC-2 auxiliary subunit provides a tangible link to leukodystrophy

Neuron. 2012 Mar 8;73(5):855-7. doi: 10.1016/j.neuron.2012.02.012.

Authors

Merritt C Maduke¹, Richard J Reimer

Affiliation

¹ Department of Molecular and Cellular Physiology, Stanford University, 279 Campus Drive West, Stanford, CA 94305, USA. maduke@stanford.edu

PMID: 22405196
DOI: 10.1016/j.neuron.2012.02.012

Abstract

ClC-2 is a broadly distributed chloride channel with an enigmatic neurophysiological function. In this issue of Neuron, Jeworutzki et al. (2012) use a biochemical approach to identify GlialCAM, a protein with a defined link to leukodystrophy, as a ClC-2 auxiliary subunit.

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