Abstract
Infective endocarditis is a common complication of Staphylococcus aureus bacteraemia, but literature reports of community-associated methicillin-resistant S. aureus (CA-MRSA) endocarditis are relatively uncommon and mostly comprise intravenous drug users (IVDUs) with the USA300 strain. We report 5 cases of CA-MRSA endocarditis in previously healthy young Australian adults, 4 in IVDUs. Morbidity was high with frequent septic emboli; 3 patients required cardiac surgery and 1 patient died. Typing revealed the 2 most common Australian strains, the Panton-Valentine leukocidin (PVL)-positive ST93 (Queensland) strain and the PVL-negative ST1 (WA-MRSA-1) strain.
MeSH terms
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Adult
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Community-Acquired Infections / epidemiology*
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Community-Acquired Infections / microbiology*
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Community-Acquired Infections / mortality
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Community-Acquired Infections / pathology
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Endocarditis / epidemiology*
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Endocarditis / microbiology*
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Endocarditis / mortality
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Endocarditis / pathology
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Female
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Humans
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Male
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Methicillin-Resistant Staphylococcus aureus / classification
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Methicillin-Resistant Staphylococcus aureus / genetics
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Methicillin-Resistant Staphylococcus aureus / isolation & purification*
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Molecular Typing
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Queensland / epidemiology
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Staphylococcal Infections / epidemiology*
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Staphylococcal Infections / microbiology*
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Staphylococcal Infections / mortality
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Staphylococcal Infections / pathology
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Substance Abuse, Intravenous / complications
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Survival Analysis
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Treatment Outcome
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Young Adult