Abstract
We previously reported that 2-fluoroloxoprofen has lower gastric ulcerogenic activity than loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID) without selectivity for COX-2. We synthesized derivatives of 2-fluoroloxoprofen and studied their properties. Compared to 2-fluoroloxoprofen, one derivative, 11a, exhibited higher anti-inflammatory activity and an equivalent ulcerogenic effect. These results suggest that 11a could be therapeutically beneficial for use as an NSAID.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aniline Compounds / adverse effects
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Aniline Compounds / chemical synthesis*
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Aniline Compounds / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Carrageenan
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Cyclooxygenase 1 / metabolism
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Cyclooxygenase 2 / metabolism
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Cyclooxygenase Inhibitors / adverse effects
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Cyclooxygenase Inhibitors / chemical synthesis
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Cyclooxygenase Inhibitors / pharmacology
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Edema / chemically induced
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Edema / drug therapy
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Humans
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Phenylpropionates / adverse effects
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Phenylpropionates / chemical synthesis*
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Phenylpropionates / pharmacology
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Rats
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Stomach Ulcer / chemically induced*
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Structure-Activity Relationship
Substances
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2-(4-(cyclopentylamino)-2-fluorophenyl)propanoic acid
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Aniline Compounds
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Phenylpropionates
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Carrageenan
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Cyclooxygenase 1
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Cyclooxygenase 2