A general stereoselective enamine mediated alkylation of α-substituted aldehydes

Andrea Gualandi; Diego Petruzziello; Enrico Emer; Pier Giorgio Cozzi

doi:10.1039/c2cc17482k

A general stereoselective enamine mediated alkylation of α-substituted aldehydes

Chem Commun (Camb). 2012 Apr 14;48(30):3614-6. doi: 10.1039/c2cc17482k. Epub 2012 Mar 6.

Authors

Andrea Gualandi¹, Diego Petruzziello, Enrico Emer, Pier Giorgio Cozzi

Affiliation

¹ Dipartimento di Chimica G. Ciamician ALMA MATER STUDIORUM Università di Bologna, via Selmi 2, 40126 Bologna, Italy.

PMID: 22396955
DOI: 10.1039/c2cc17482k

Abstract

We herein present a general enamine-mediated α-alkylation of α-substituted aldehydes with carbenium ions for the stereoselective construction of quaternary stereogenic centers.