Investigation of encapsulation of insulin biotemplate within C-methylresorcin[4]arenes

Harshita Kumari; Steven R Kline; Jerry L Atwood

doi:10.1039/c2cc18071e

Investigation of encapsulation of insulin biotemplate within C-methylresorcin[4]arenes

Chem Commun (Camb). 2012 Apr 14;48(30):3599-601. doi: 10.1039/c2cc18071e. Epub 2012 Mar 5.

Authors

Harshita Kumari¹, Steven R Kline, Jerry L Atwood

Affiliation

¹ Department of Chemistry, University of Missouri-Columbia, 601 S. College Avenue, Columbia, MO 65211, USA.

PMID: 22392225
DOI: 10.1039/c2cc18071e

Abstract

Solution structure of insulin templated C-methyl resorcin[4]arene nanocapsules has been investigated using neutron scattering. The insulin biotemplate has enhanced the limits of encapsulation and enabled formation of a larger spherical molecular host.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Calixarenes / chemistry*
Insulin Lispro / chemistry*
Nanocapsules / chemistry*
Neutron Diffraction
Scattering, Small Angle

Substances

Insulin Lispro
Nanocapsules
Calixarenes