A spatio-temporal absorbing state model for disease and syndromic surveillance

Stat Med. 2012 Aug 30;31(19):2123-36. doi: 10.1002/sim.5350. Epub 2012 Mar 2.

Abstract

Reliable surveillance models are an important tool in public health because they aid in mitigating disease outbreaks, identify where and when disease outbreaks occur, and predict future occurrences. Although many statistical models have been devised for surveillance purposes, none are able to simultaneously achieve the important practical goals of good sensitivity and specificity, proper use of covariate information, inclusion of spatio-temporal dynamics, and transparent support to decision-makers. In an effort to achieve these goals, this paper proposes a spatio-temporal conditional autoregressive hidden Markov model with an absorbing state. The model performs well in both a large simulation study and in an application to influenza/pneumonia fatality data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bayes Theorem
  • Computer Simulation
  • Disease Outbreaks / statistics & numerical data*
  • Humans
  • Influenza, Human / epidemiology*
  • Markov Chains
  • Poisson Distribution
  • Population Surveillance / methods*
  • Space-Time Clustering*
  • Syndrome
  • United States / epidemiology