Role of 5-hydroxytryptamine2C receptors in marble-burying behavior in mice

Biol Pharm Bull. 2012;35(3):376-9. doi: 10.1248/bpb.35.376.

Abstract

We examined the role of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT(2C) agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT(2C) antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT(2C) receptors play a role in marble-burying behavior in mice.

MeSH terms

  • Aminopyridines / pharmacology
  • Amphetamines / pharmacology
  • Animals
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology*
  • Fluoxetine / pharmacology
  • Indoles / pharmacology
  • Male
  • Mice
  • Mice, Inbred ICR
  • Motor Activity / drug effects
  • Obsessive-Compulsive Disorder / drug therapy
  • Paroxetine / pharmacology
  • Receptor, Serotonin, 5-HT2C / physiology*
  • Selective Serotonin Reuptake Inhibitors / pharmacology*
  • Serotonin 5-HT2 Receptor Agonists / pharmacology*
  • Serotonin 5-HT2 Receptor Antagonists / pharmacology

Substances

  • 6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline
  • Aminopyridines
  • Amphetamines
  • Indoles
  • Receptor, Serotonin, 5-HT2C
  • Serotonin 5-HT2 Receptor Agonists
  • Serotonin 5-HT2 Receptor Antagonists
  • Serotonin Uptake Inhibitors
  • Fluoxetine
  • Paroxetine
  • 4-iodo-2,5-dimethoxyphenylisopropylamine