Abstract
We examined the role of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT(2C) agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT(2C) antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT(2C) receptors play a role in marble-burying behavior in mice.
MeSH terms
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Aminopyridines / pharmacology
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Amphetamines / pharmacology
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Animals
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Behavior, Animal / drug effects
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Behavior, Animal / physiology*
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Fluoxetine / pharmacology
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Indoles / pharmacology
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Male
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Mice
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Mice, Inbred ICR
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Motor Activity / drug effects
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Obsessive-Compulsive Disorder / drug therapy
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Paroxetine / pharmacology
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Receptor, Serotonin, 5-HT2C / physiology*
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Selective Serotonin Reuptake Inhibitors / pharmacology*
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Serotonin 5-HT2 Receptor Agonists / pharmacology*
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Serotonin 5-HT2 Receptor Antagonists / pharmacology
Substances
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6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline
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Aminopyridines
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Amphetamines
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Indoles
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Receptor, Serotonin, 5-HT2C
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Serotonin 5-HT2 Receptor Agonists
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Serotonin 5-HT2 Receptor Antagonists
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Serotonin Uptake Inhibitors
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Fluoxetine
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Paroxetine
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4-iodo-2,5-dimethoxyphenylisopropylamine