Dexamethasone treatment has no effect on the formation of pneumococcal antibodies during community-acquired pneumonia

Clin Vaccine Immunol. 2012 May;19(5):811-3. doi: 10.1128/CVI.05697-11. Epub 2012 Feb 29.

Abstract

In this study, the effect of dexamethasone on the formation of pneumococcal antibodies during community-acquired pneumonia (CAP) was investigated. No differences between CAP patients receiving dexamethasone as additional therapy and patients receiving a placebo were found with respect to immune response rates and mean baseline and convalescent-phase antibody concentrations.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Bacterial / blood*
  • Antineoplastic Agents / administration & dosage*
  • Community-Acquired Infections / immunology*
  • Dexamethasone / administration & dosage*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Placebos / administration & dosage
  • Pneumonia, Pneumococcal / immunology*

Substances

  • Antibodies, Bacterial
  • Antineoplastic Agents
  • Placebos
  • Dexamethasone