Abstract
The first total synthesis of 6'-hydroxyjusticidin A, isolated from Justicia procumbens L. with good inhibitory activity against cancer cells, has been accomplished. The structure was confirmed by ¹H NMR, ¹³C NMR, and HR-ESI-MS. The key steps involved a Diels-Alder cycloaddition reaction and a reduction in NaBH₄.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acanthaceae / chemistry
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Antineoplastic Agents, Phytogenic / chemical synthesis*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Dioxolanes / chemical synthesis*
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Dioxolanes / chemistry
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Dioxolanes / pharmacology
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Humans
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Lignans / chemical synthesis*
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Lignans / chemistry
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Lignans / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Stereoisomerism
Substances
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Antineoplastic Agents, Phytogenic
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Dioxolanes
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Lignans
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6'-hydroxyjusticidin A