Pyrrolidinyl peptide nucleic acid homologues: effect of ring size on hybridization properties

Org Lett. 2012 Mar 16;14(6):1440-3. doi: 10.1021/ol300190u. Epub 2012 Feb 29.

Abstract

The effect of ring size of four- to six-membered cyclic β-amino acid on the hybridization properties of pyrrolidinyl peptide nucleic acid with an alternating α/β peptide backbone is reported. The cyclobutane derivatives (acbcPNA) show the highest T(m) and excellent specificity with cDNA and RNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cyclobutanes / chemistry
  • DNA / chemistry
  • Molecular Structure
  • Nucleic Acid Hybridization
  • Peptide Nucleic Acids / chemical synthesis
  • Peptide Nucleic Acids / chemistry*
  • RNA / chemistry

Substances

  • Cyclobutanes
  • Peptide Nucleic Acids
  • RNA
  • DNA