Abstract
The effect of ring size of four- to six-membered cyclic β-amino acid on the hybridization properties of pyrrolidinyl peptide nucleic acid with an alternating α/β peptide backbone is reported. The cyclobutane derivatives (acbcPNA) show the highest T(m) and excellent specificity with cDNA and RNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Cyclobutanes / chemistry
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DNA / chemistry
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Molecular Structure
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Nucleic Acid Hybridization
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Peptide Nucleic Acids / chemical synthesis
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Peptide Nucleic Acids / chemistry*
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RNA / chemistry
Substances
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Cyclobutanes
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Peptide Nucleic Acids
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RNA
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DNA