Comparison of the genetic structures surrounding qnrA1 in Korean Enterobacter cloacae and Chinese Escherichia coli strains isolated in the early 2000s: evidence for qnrA mobilization via Inc HI2 type plasmid

Sang Hoon Han; Young Ah Kim; Minggui Wang; Yangsoon Lee; Hae-Sun Chung; Jong Hwa Yum; Dongeun Yong; Kyungwon Lee; June Myung Kim

doi:10.1007/s12275-012-1350-z

Comparison of the genetic structures surrounding qnrA1 in Korean Enterobacter cloacae and Chinese Escherichia coli strains isolated in the early 2000s: evidence for qnrA mobilization via Inc HI2 type plasmid

J Microbiol. 2012 Feb;50(1):166-9. doi: 10.1007/s12275-012-1350-z. Epub 2012 Feb 27.

Authors

Sang Hoon Han¹, Young Ah Kim, Minggui Wang, Yangsoon Lee, Hae-Sun Chung, Jong Hwa Yum, Dongeun Yong, Kyungwon Lee, June Myung Kim

Affiliation

¹ Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, 120-752, Republic of Korea.

PMID: 22367953
DOI: 10.1007/s12275-012-1350-z

Abstract

The flanking genetic structure of qnrA1 in Korean Enterobacter loacae was identical to that of the Chinese Escherichia coli strain, the first qnrA1-carrying strain reported in Asia. Analysis of restriction enzyme sites and Southern blot hybridization results showed that qnrA1 was transferred between E. cloacae and E. coli via Inc HI2 type plasmid.

MeSH terms

Blotting, Southern
China
Enterobacter cloacae / genetics*
Enterobacter cloacae / isolation & purification*
Enterobacteriaceae Infections / microbiology*
Escherichia coli / genetics*
Escherichia coli / isolation & purification*
Gene Order
Gene Transfer, Horizontal*
Genes, Bacterial*
Humans
Plasmids
Republic of Korea
Restriction Mapping
Sequence Homology
Synteny