Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors

Nat Prod Rep. 2012 May 1;29(5):555-67. doi: 10.1039/c2np00100d. Epub 2012 Feb 27.

Abstract

Covering: up to the end of 2011. This review covers classical and modern structural modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and analogues, and the pharmacology of these compounds, with emphasis on their interactions with nicotinic receptors. 89 references are cited.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkaloids / chemical synthesis
  • Alkaloids / chemistry
  • Alkaloids / pharmacology*
  • Animals
  • Azocines / chemical synthesis
  • Azocines / chemistry
  • Azocines / pharmacology
  • Biological Products / pharmacology*
  • Humans
  • Molecular Structure
  • Quinolizines / chemical synthesis
  • Quinolizines / chemistry
  • Quinolizines / pharmacology
  • Rats
  • Receptors, Nicotinic / drug effects*

Substances

  • Alkaloids
  • Azocines
  • Biological Products
  • Quinolizines
  • Receptors, Nicotinic
  • cytisine