Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process

Org Biomol Chem. 2012 Apr 7;10(13):2537-41. doi: 10.1039/c2ob25075f. Epub 2012 Feb 27.

Abstract

3,4-Dihydrocoumarins, considered to be valuable building blocks, have attracted considerable attention due to their various biological activities. Herein, we have documented an efficient and convenient double decarboxylation process for the synthesis of 4-substituted 3,4-dihydrocoumarin in moderate to excellent yields under mild reaction conditions (up to 98%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / chemistry
  • Catalysis
  • Coumarins / chemical synthesis*
  • Cyclization
  • Decarboxylation
  • Molecular Structure

Substances

  • Biological Products
  • Coumarins
  • 3,4-dihydrocoumarin