A hybrid operating suite, where craniotomy, brain CT scanning, fluoroscopy, and angiography can be performed on the same operating table, is becoming popular among neurosurgeons. However, whether use of a hybrid operating suite can improve neurological outcome has not been studied. We reviewed the incidence and outcomes of ruptures of cerebral vascular lesions during interventional neuroradiology procedures performed in our hybrid operating suite. Of 602 patients who underwent coil embolization under general anesthesia, five cases of intraprocedural rupture of the aneurysms were identified. Despite emergency neurosurgical intervention within 2 h of rupture of the aneurysms, two of these five patients died and one patient had permanent neurological deficit postsurgery. Whether use of a hybrid operating suite improves neurological outcome remains uncertain.