Effective use of mass spectrometry for glycan and glycopeptide structural analysis

Anal Chem. 2012 Apr 3;84(7):3040-8. doi: 10.1021/ac3000573. Epub 2012 Mar 6.

Abstract

Most proteins are glycosylated. Mass spectrometry methods are used for mapping glycoprotein glycosylation and detailed glycan structural determination. This technology enables precise characterization of recombinant glycoproteins in the pharmaceutical industry and academic biomedicine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Glycopeptides / chemistry*
  • Glycopeptides / metabolism
  • Humans
  • Mass Spectrometry / methods*
  • Molecular Sequence Data
  • Polysaccharides / chemistry*
  • Polysaccharides / metabolism

Substances

  • Glycopeptides
  • Polysaccharides