Abstract
In addition to genetic alterations of gains and losses, epigenetic events of promoter methylation appear to further undermine a destabilized genomic repertoire in squamous head and neck carcinoma (HNSCC). This chapter provides an overview of frequently methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck tumorigenesis.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Biomarkers, Tumor / metabolism*
-
Cell Line, Tumor
-
Cell Transformation, Neoplastic / genetics
-
Cell Transformation, Neoplastic / metabolism*
-
DNA Methylation / genetics
-
DNA Methylation / physiology*
-
DNA Probes
-
Epigenesis, Genetic*
-
Genes, Tumor Suppressor*
-
Head and Neck Neoplasms / genetics
-
Head and Neck Neoplasms / metabolism*
-
Humans
-
Promoter Regions, Genetic / genetics*
-
Real-Time Polymerase Chain Reaction
Substances
-
Biomarkers, Tumor
-
DNA Probes