Expanding the regioselective enzymatic repertoire: oxidative mono-cleavage of dialkenes catalyzed by Trametes hirsuta

Chem Commun (Camb). 2012 Apr 4;48(27):3303-5. doi: 10.1039/c2cc17572j. Epub 2012 Feb 22.

Abstract

The first report of a biocatalytic regioselective oxidative mono-cleavage of dialkenes was successfully achieved employing a cell-free enzyme preparation from Trametes hirsuta at the expense of molecular oxygen. Selected reactions were performed on a preparative scale affording high to excellent conversions and chemoselectivities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis
  • Alkenes / metabolism*
  • Benzaldehydes / chemistry
  • Benzaldehydes / metabolism*
  • Biocatalysis
  • Cell-Free System
  • Oxidation-Reduction
  • Oxygen / chemistry
  • Stereoisomerism
  • Substrate Specificity
  • Trametes / enzymology*

Substances

  • Alkenes
  • Benzaldehydes
  • Oxygen