Corn silk is well known and frequently used in traditional Chinese herbal medicines. Polysaccharides of corn silk (POCS), which were extracted by distilled water and precipitated by 80% ethanol solution, were evaluated for its anti-diabetic effect on streptozotocin (STZ)-induced diabetic rats. The results demonstrated that daily treatment with 100-500 mg/kg body weight of POCS on the diabetic rats could not only lead a significant decrease on the animal's blood glucose (BG) level, but also reduce the serum lipid level including total cholesterol (TC) and total triglyceride (TG) after determination. The oral glucose tolerance test (OGTT) was also performed to evaluate hypoglycemic effects. Through the measurements of measuring autonomic activity times and rolling stick times, the results also exhibited that the animals had been depressed by dimethyl-biguanide, but protected by the POCS. The POCS showed good antidepressant activity and lengthened remarkably the activity time during the autonomic activities test and exhibited a dose dependent activity.
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