Abstract
This study focused on understanding the signaling mechanisms leading to GLUT-4 translocation and increased skeletal-muscle glucose uptake that follow creatine (Cr) supplementation in type 2 diabetes (n = 10). AMPK-α protein content presented a tendency to be higher (p = 0.06) after Cr supplementation (5 g/d for 12w). The changes in AMPK-α protein content significantly related (p < 0.001) to the changes in GLUT-4 translocation (r = 0.78) and Hb1Ac levels (r = -0.68), suggesting that AMPK signaling may be implicated in the effects of supplementation on glucose uptake in type 2 diabetes.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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AMP-Activated Protein Kinases / genetics
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AMP-Activated Protein Kinases / metabolism*
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Antigens, CD / genetics
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Antigens, CD / metabolism
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Biopsy
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Creatine / pharmacology*
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Creatine / therapeutic use
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / metabolism
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Double-Blind Method
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Female
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Gene Expression Regulation / drug effects
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Glucose / metabolism*
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Glucose Transporter Type 4 / genetics
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Glucose Transporter Type 4 / metabolism
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Humans
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Male
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Middle Aged
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Mitogen-Activated Protein Kinase 1 / genetics
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Mitogen-Activated Protein Kinase 1 / metabolism
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Mitogen-Activated Protein Kinase 3 / genetics
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Mitogen-Activated Protein Kinase 3 / metabolism
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Muscle, Skeletal / drug effects*
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Muscle, Skeletal / metabolism
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Protein Transport / drug effects
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Proto-Oncogene Proteins c-akt / genetics
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Proto-Oncogene Proteins c-akt / metabolism
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Receptor, Insulin / genetics
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Receptor, Insulin / metabolism
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Signal Transduction / drug effects
Substances
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Antigens, CD
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Glucose Transporter Type 4
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INSR protein, human
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Receptor, Insulin
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Proto-Oncogene Proteins c-akt
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Mitogen-Activated Protein Kinase 1
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Mitogen-Activated Protein Kinase 3
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AMP-Activated Protein Kinases
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Glucose
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Creatine