A PIP Gets the plasmodium protein export pathway going

Rays H Y Jiang; Matthias Marti

doi:10.1016/j.chom.2012.01.011

A PIP Gets the plasmodium protein export pathway going

Cell Host Microbe. 2012 Feb 16;11(2):99-100. doi: 10.1016/j.chom.2012.01.011.

Authors

Rays H Y Jiang¹, Matthias Marti

Affiliation

¹ The Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.

PMID: 22341457
DOI: 10.1016/j.chom.2012.01.011

Abstract

Survival of blood stage malaria parasites requires extensive host cell remodeling, which is facilitated by secretion of parasite proteins via a dedicated protein export pathway. In a recent Cell paper, Bhattacharjee et al., (2012) describe PI(3)P binding as one of the first steps in targeting parasite proteins to the host cell.

MeSH terms

Host-Pathogen Interactions*
Phosphatidylinositol Phosphates / metabolism*
Plasmodium / pathogenicity*
Protozoan Proteins / metabolism*
Virulence Factors / metabolism

Substances

Phosphatidylinositol Phosphates
Protozoan Proteins
Virulence Factors
phosphatidylinositol 3-phosphate