Abstract
Cefoxitin-resistant Escherichia coli (n = 109) and Klebsiella pneumoniae (n = 16) isolates collected from patients in India in 2009 to 2010 were screened for bla(ampC) families and mobilizing elements (ISEcp1, IS26, ISCR1, and sul-1-type class 1 integrons) and their association with bla(ampC) and for the occurrence of class A beta-lactamases (BLs) (CTX-M, TEM, and SHV). The concurrent occurrences of two distinct AmpC families (bla(CIT) and bla(EBC)) and of class A with class C beta-lactamase were observed. All but one of the isolates harboring CTX-M extended-spectrum BLs (ESBLs) were carrying bla(CTX-M) genogroup 1; the remaining isolate carried bla(CTX-M) genogroup 9. The mobilizing elements occurred in different combinations in the study isolates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Cefoxitin / pharmacology
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Escherichia coli / enzymology*
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Escherichia coli / genetics*
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Escherichia coli / isolation & purification
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Escherichia coli Infections / microbiology
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Humans
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India
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Integrons*
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Interspersed Repetitive Sequences*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Molecular Sequence Data
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Sequence Analysis, DNA
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beta-Lactam Resistance
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Cefoxitin
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beta-Lactamases
Associated data
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GENBANK/JF918432
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GENBANK/JF918433
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GENBANK/JF918434
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GENBANK/JF918435