A turn-on two-photon fluorescent probe for ATP and ADP

Chem Commun (Camb). 2012 Mar 28;48(26):3206-8. doi: 10.1039/c2cc17629g. Epub 2012 Feb 13.

Abstract

An acedan derivative containing Zn(II)-DPA has been developed as a two-photon probe for nucleoside phosphates, which shows enhanced fluorescence toward ATP and ADP at physiological pH 7.4 among other competing anions including AMP; the probe is permeable to cell membranes and thus can be directly used for two-photon imaging of ATP and ADP in live cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Diphosphate / chemistry*
  • Adenosine Triphosphate / chemistry*
  • Amines / chemistry
  • Cell Membrane / chemistry
  • Cells, Cultured
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Humans
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry*
  • Photons*
  • Picolinic Acids / chemistry
  • Zinc / chemistry

Substances

  • 2,2'-dipicolylamine
  • Amines
  • Fluorescent Dyes
  • Organometallic Compounds
  • Picolinic Acids
  • Adenosine Diphosphate
  • Adenosine Triphosphate
  • Zinc