Abstract
A kinetic resolution of α-allenic alcohols is realized through chiral silver phosphate-catalyzed cycloisomerization with high stereoselectivity (selectivity factor up to 189) and tolerance of a variety of functional groups. A mechanistic model is proposed to interpret the origin of the high stereoselectivity and broad substrate scope.
© 2012 American Chemical Society
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohols / chemical synthesis*
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Alcohols / chemistry
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Alkadienes / chemical synthesis*
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Alkadienes / chemistry
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Catalysis
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Cyclization
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Kinetics
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Molecular Structure
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Phosphates / chemistry*
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Silver Compounds / chemistry*
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Stereoisomerism
Substances
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Alcohols
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Alkadienes
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Phosphates
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Silver Compounds
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silver phosphate