How to activate a gene: decap its associated noncoding RNA

Madhuvanthi Ramaiah; Eleen Y Shum; Miles F Wilkinson

doi:10.1016/j.molcel.2012.01.014

How to activate a gene: decap its associated noncoding RNA

Mol Cell. 2012 Feb 10;45(3):271-3. doi: 10.1016/j.molcel.2012.01.014.

Authors

Madhuvanthi Ramaiah¹, Eleen Y Shum, Miles F Wilkinson

Affiliation

¹ Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0695, USA.

Abstract

Capped and polyadenylated long noncoding RNAs (lncRNAs) are shown to be degraded by a DCP2-mediated turnover mechanism by Geisler et al. (2012); this provides a new level of regulatory control for inducible genes by lncRNAs.

Publication types

Comment

MeSH terms

Exoribonucleases / genetics*
Gene Expression Regulation, Fungal*
RNA Caps / metabolism*
RNA Processing, Post-Transcriptional*
RNA, Untranslated / metabolism*
Saccharomyces cerevisiae / genetics*
Saccharomyces cerevisiae Proteins / genetics*

Substances

RNA Caps
RNA, Untranslated
Saccharomyces cerevisiae Proteins
RAT1 protein, S cerevisiae
Exoribonucleases

Grants and funding

R01 GM058595/GM/NIGMS NIH HHS/United States