Executive attention and working memory in narcoleptic outpatients

Arq Neuropsiquiatr. 2012 May;70(5):335-40. doi: 10.1590/s0004-282x2012005000007. Epub 2012 Feb 9.

Abstract

Objective: This pioneering study aimed to evaluate executive attention and working memory in Brazilian narcoleptic outpatients.

Methods: Narcoleptic group: 19 treated narcoleptic outpatients (13 F; 6 M) (mean age=37.58; SD = 8.93); control group: 19 subjects (15 F; 4 M) (mean age=34.42; SD=12.31).

Instruments: Epworth Sleepiness Scale - Brazilian Portuguese Version (ESS-BR), Victoria Stroop Test (VST), Trail Making Test (TMT) and Letter-Number Sequencing (LNS) of WAIS-III.

Results: Significant difference at Excessive Daytime Sleepiness (EDS) (p<0.001) and at working memory (p=0.009) with worse results for narcoleptic patients. Patients were slower at VST-1 (p=0.002), VST-2 (p=0.045) and at TMT-A (p=0.016), TMT-B (p=0.006) and B-A (p=0.024).

Conclusion: Narcoleptic patients showed higher degrees of EDS, an impaired executive attention at a temporal level and lower performance in working memory when compared to normal controls.

MeSH terms

  • Adult
  • Attention / physiology*
  • Case-Control Studies
  • Executive Function / physiology*
  • Female
  • Humans
  • Male
  • Memory, Short-Term / physiology*
  • Middle Aged
  • Narcolepsy / physiopathology*
  • Neuropsychological Tests
  • Outpatients
  • Prospective Studies
  • Psychomotor Performance / physiology*
  • Severity of Illness Index
  • Socioeconomic Factors
  • Young Adult